SERVICE SPECIFICATION

Apixmed Prism

(Integral part of the Public Offer)

Edition of November 3, 2026

1. GENERAL PROVISIONS

1.1. This Specification is an integral part of the Apixmed Prism Public Offer and defines the list of available Services, their composition and cost.

1.2. Each Service includes a DNA kit for saliva collection and laboratory DNA analysis. The kit is delivered by Nova Poshta. Purchasing a DNA kit without interpretation is impossible — each order includes at least one Test of the Customer's choice. The Contractor may refuse to provide the service if the Customer did not collect the biomaterial (saliva) of sufficient quality for analysis (determined by the laboratory).

1.3. The results are presented in the Personal Account (online) and/or sent in PDF format to the Customer's email. The terms of provision are determined by the Public Offer.

1.4. All results are for informational purposes only and do not constitute a medical diagnosis.

1.5. The indicators of each Test are presented in two groups: complex indicators calculated by the polygenic risk score method (tens and hundreds of genetic variants together shape the contribution to a predisposition), and individual genetic variants with a described mechanistic link, which are interpreted separately and are not included in the complex indicators.

2. COST OF SERVICES

2.1. Current prices for Services:

1. DNA kit + 1 Test of your choice: 9,999 UAH (price without discount — 12,500 UAH)
2. Wellness Panel (DNA kit + 5 Tests): 17,200 UAH (price without discount — 22,500 UAH)
3. Ultima Panel (DNA kit + 25 Tests + specialist consultation): 29,999 UAH (price without discount — 50,000 UAH)

2.2. Prices are indicated in hryvnias (UAH). Payment is made online by bank card on the Site or by bank transfer to the details of the Contractor. The cost of DNA kit delivery is included in the price of the Service.

2.3. The Contractor reserves the right to change prices in accordance with clause 12.4 of the Public Offer. Changes do not apply to already paid orders.

2.4. The Contractor may provide special offers and discounts; all prices are indicated for informational purposes, and the final price at which the Customer purchased the Service is the one that applies.

3. DNA KIT

3.1. DNA kit is a means of collecting biomaterial (saliva), which is included in every Service. Purchasing a DNA kit separately without interpreting at least one Test is impossible.

3.2. The DNA kit includes:

1. Saliva collection kit from the manufacturer
2. Protective gloves
3. Sample packaging envelope
4. Step-by-step instructions for collecting biomaterial

3.3. Upon completion of the laboratory analysis, the Customer receives a raw genetic data file in a format compatible with Apixmed Prism interpretation services.

4. TESTS (SEPARATE SERVICES)

4.1. A Test is a separate Service with a specific thematic list of genetic indicators. The Apixmed Prism programme comprises 26 Tests (directions). A Test is ordered together with a DNA kit and laboratory analysis.

4.2. Vitamins and Micronutrients

Number of indicators: 58 (30 complex indicators and 28 individual genetic variants).

Complex indicators — type: polygenic risk

Fat-soluble vitamins

1. Vitamin A (retinol) — polygenic risk
2. Vitamin D (25(OH)D) — polygenic risk
3. Vitamin D-binding protein — polygenic risk
4. Vitamin E — polygenic risk
5. Vitamin K1 (phylloquinone) — polygenic risk

Water-soluble vitamins and transport proteins

1. Vitamin B1 (thiamine) — polygenic risk
2. Vitamin B3 (niacin) — polygenic risk
3. Vitamin B5 (pantothenic acid) — polygenic risk
4. Vitamin B6 — polygenic risk
5. Vitamin B9 (folate) — polygenic risk
6. Vitamin B12 (cobalamin) — polygenic risk
7. Transcobalamin-1 — polygenic risk
8. Vitamin C — polygenic risk

Carotenoids

1. Lycopene — polygenic risk

Electrolytes

1. Sodium — polygenic risk
2. Potassium — polygenic risk
3. Chloride — polygenic risk

Macrominerals

1. Calcium — polygenic risk
2. Phosphorus — polygenic risk
3. Magnesium — polygenic risk

Iron status

1. Iron — polygenic risk
2. Ferritin — polygenic risk
3. Transferrin — polygenic risk
4. Total iron-binding capacity — polygenic risk
5. Transferrin saturation — polygenic risk

Trace elements

1. Zinc — polygenic risk
2. Selenium — polygenic risk
3. Copper — polygenic risk
4. Molybdenum — polygenic risk
5. Cobalt — polygenic risk

Individual genetic variants — type: functional variant

1. CYP24A1 rs6068816 [vitamin D catabolism] — functional variant
2. CYP2R1 rs10741657 [25-hydroxyvitamin D] — functional variant
3. CYP2R1 rs7129781 [vitamin D 25-hydroxylation] — functional variant
4. DHCR7/NADSYN1 rs12785878 [vitamin D precursor synthesis] — functional variant
5. GC rs2282679 [25-hydroxyvitamin D; vitamin-D binding protein] — functional variant
6. GC rs4588 [vitamin D transport] — functional variant
7. GC rs7041 [vitamin D transport] — functional variant
8. GC rs705117 [vitamin D transport] — functional variant
9. NADSYN1 rs12286616 [vitamin D precursor synthesis] — functional variant
10. POR rs41301394 [P450 oxidoreductase, vitamin D enzymes] — functional variant
11. SULT2A1 rs2910400 [vitamin D metabolite sulfation] — functional variant
12. VDR FokI (rs2228570) [vitamin D] — functional variant
13. CYP4F2 V433M (rs2108622) [vitamin K / warfarin] — functional variant
14. ALPL (rs1256335) — functional variant
15. NBPF3 (rs4654748) — functional variant
16. MTHFR A1298C (rs1801131) [folate & homocysteine] — functional variant
17. MTHFR C677T (rs1801133) [folate & homocysteine] — functional variant
18. FUT2 W143X (rs601338) [secretor status] — functional variant
19. CUBN Phe253Ser (rs1801222) [cobalamin absorption] — functional variant
20. TCN2 C776G (rs1801198) [vitamin B12 transport] — functional variant
21. SLC23A1 rs33972313 [vitamin C] — functional variant
22. BCO1 rs12934922 [carotenoid→vitamin A] — functional variant
23. BCO1 rs7501331 [carotenoid→vitamin A] — functional variant
24. CASR A986S (rs1801725) [calcium] — functional variant
25. HFE H63D (rs1799945) [iron overload / hemochromatosis] — functional variant
26. HFE C282Y (rs1800562) [iron overload / hemochromatosis] — functional variant
27. TMPRSS6 V736A (rs855791) [iron status] — functional variant
28. TF rs3811647 — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Electrolytes (combined profile) — composite score
2. Iron status (combined profile) — composite score

4.3. Amino Acids

Number of indicators: 43 (36 complex indicators and 7 individual genetic variants).

Complex indicators — type: polygenic risk

Branched-chain amino acids (BCAA)

1. Leucine — polygenic risk
2. Isoleucine — polygenic risk
3. Valine — polygenic risk

Other essential amino acids

1. Histidine — polygenic risk
2. Lysine — polygenic risk
3. Methionine — polygenic risk
4. Threonine — polygenic risk
5. Tryptophan — polygenic risk
6. Phenylalanine — polygenic risk

Conditionally essential amino acids

1. Arginine — polygenic risk
2. Glycine — polygenic risk
3. Glutamine — polygenic risk
4. Proline — polygenic risk
5. Tyrosine — polygenic risk
6. Cysteine — polygenic risk

Non-essential amino acids

1. Alanine — polygenic risk
2. Asparagine — polygenic risk
3. Aspartate — polygenic risk
4. Glutamate — polygenic risk
5. Serine — polygenic risk

Urea cycle and methylated arginine derivatives

1. Ornithine — polygenic risk
2. Citrulline — polygenic risk
3. Symmetric dimethylarginine (SDMA) — polygenic risk

Markers of one-carbon and related metabolism

1. Homocysteine — polygenic risk
2. Cystathionine — polygenic risk
3. Betaine — polygenic risk
4. Dimethylglycine (DMG) — polygenic risk
5. Sarcosine — polygenic risk
6. Methylmalonic acid (MMA) — polygenic risk

Tryptophan, kynurenine and other bioactive derivatives

1. Kynurenine — polygenic risk
2. Kynurenic acid — polygenic risk
3. Taurine — polygenic risk

Creatine, muscle and structural metabolism

1. Creatine — polygenic risk
2. Guanidinoacetate — polygenic risk
3. Beta-alanine — polygenic risk

Energy and enzyme markers

1. Lactate — polygenic risk

Individual genetic variants — type: functional variant

1. CPS1 Thr1406Asn (rs1047891) [glycine / urea cycle] — functional variant
2. AGXT2 Val140Ile (rs37369) [methylated arginine / BP] — functional variant
3. MTHFD1 Arg653Gln (rs2236225) [folate cycle] — functional variant
4. MTHFR A1298C (rs1801131) [folate & homocysteine] — functional variant
5. MTHFR C677T (rs1801133) [folate & homocysteine] — functional variant
6. MTR Asp919Gly (rs1805087) [methionine synthase] — functional variant
7. MTRR Ile22Met (rs1801394) [one-carbon metabolism] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Conditionally essential amino acids (combined profile) — composite score

4.4. Blood Biomarkers

Number of indicators: 52 (46 complex indicators and 6 individual genetic variants).

Complex indicators — type: polygenic risk

Red blood cells and red cell indices

1. Hemoglobin — polygenic risk
2. Red blood cell count (RBC) — polygenic risk
3. Hematocrit (HCT) — polygenic risk
4. Mean corpuscular volume (MCV) — polygenic risk
5. Mean corpuscular hemoglobin (MCH) — polygenic risk
6. Mean corpuscular hemoglobin concentration (MCHC) — polygenic risk
7. Red cell distribution width (RDW) — polygenic risk

White blood cell profile

1. White blood cell count (WBC) — polygenic risk
2. Neutrophil count — polygenic risk
3. Lymphocyte count — polygenic risk
4. Monocyte count — polygenic risk
5. Eosinophil count — polygenic risk
6. Basophil count — polygenic risk

Platelets and coagulation

1. Platelet count — polygenic risk
2. Mean platelet volume (MPV) — polygenic risk
3. Blood clotting — polygenic risk

Iron status

1. Iron — polygenic risk
2. Ferritin — polygenic risk
3. Transferrin — polygenic risk
4. Total iron-binding capacity — polygenic risk
5. Transferrin saturation — polygenic risk

Circulating metabolic and lipid markers

1. Total cholesterol — polygenic risk
2. High-density lipoprotein (HDL) cholesterol — polygenic risk
3. Very-low-density lipoprotein (VLDL) cholesterol — polygenic risk
4. Apolipoprotein A-I — polygenic risk
5. Lipoprotein(a) [Lp(a)] — polygenic risk
6. Glycated hemoglobin — polygenic risk
7. Uric acid — polygenic risk

Hematological conditions

1. Anemia — polygenic risk
2. Immune thrombocytopenia — polygenic risk

Liver markers and plasma proteins

1. Alanine aminotransferase (ALT) — polygenic risk
2. Aspartate aminotransferase (AST) — polygenic risk
3. Alkaline phosphatase (ALP) — polygenic risk
4. Bilirubin — polygenic risk
5. Albumin — polygenic risk

Pancreatic and tissue enzyme markers

1. Amylase — polygenic risk
2. Lipase — polygenic risk
3. Creatine kinase — polygenic risk

Thrombotic conditions

1. Thromboembolism — polygenic risk
2. Deep vein thrombosis — polygenic risk
3. Venous thromboembolism — polygenic risk
4. Thrombophilia — polygenic risk
5. Phlebitis — polygenic risk
6. Varicose veins — polygenic risk

Inflammation markers

1. C-reactive protein — polygenic risk
2. Fibrinogen — polygenic risk

Individual genetic variants — type: functional variant

1. F2 G20210A (rs1799963) [thrombophilia] — functional variant
2. F5 Leiden (rs6025) [thrombophilia] — functional variant
3. FGB −455G>A (rs1800790) [fibrinogen] — functional variant
4. TMPRSS6 V736A (rs855791) [iron status] — functional variant
5. ABCG2 Q141K (rs2231142) [uric acid / gout] — functional variant
6. IL6R Asp358Ala (rs2228145) [inflammation (IL-6)] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Red blood cell indices (combined profile) — composite score
2. White blood cell profile (combined profile) — composite score
3. Circulating metabolic & lipid markers (combined profile) — composite score

4.5. Lipids, Cholesterol and Fatty Acids

Number of indicators: 50 (33 complex indicators and 17 individual genetic variants).

Complex indicators — type: polygenic risk

Omega-3 fatty acids

1. Alpha-linolenic acid (ALA) — polygenic risk
2. Eicosapentaenoic acid (EPA) — polygenic risk
3. Docosapentaenoic acid (DPA) — polygenic risk
4. Docosahexaenoic acid (DHA) — polygenic risk

Omega-6 fatty acids and balance

1. Omega-6 fatty acids — polygenic risk
2. Linoleic acid (LA) — polygenic risk
3. Gamma-linolenic acid (GLA) — polygenic risk
4. Dihomo-gamma-linolenic acid (DGLA) — polygenic risk
5. Arachidonic acid (ARA) — polygenic risk
6. Omega-6/omega-3 ratio — polygenic risk

Fatty acid classes and chain length

1. Saturated fatty acids (SFA) — polygenic risk
2. Very-long-chain saturated fatty acids (VLC-SFA) — polygenic risk
3. Monounsaturated fatty acids (MUFA) — polygenic risk
4. Oleic acid — polygenic risk

Bioactive lipids and related compounds

1. Coenzyme Q10 — polygenic risk
2. Choline — polygenic risk
3. Ceramide — polygenic risk

Cholesterol and triglyceride profile

1. Total cholesterol — polygenic risk
2. Low-density lipoprotein (LDL) cholesterol — polygenic risk
3. High-density lipoprotein (HDL) cholesterol — polygenic risk
4. Triglycerides — polygenic risk
5. Non-HDL cholesterol — polygenic risk
6. Very-low-density lipoprotein (VLDL) cholesterol — polygenic risk
7. Remnant cholesterol — polygenic risk

Apolipoproteins and lipoprotein particles

1. Apolipoprotein A-I — polygenic risk
2. Apolipoprotein B (ApoB) — polygenic risk
3. Apolipoprotein B-to-apolipoprotein A-I ratio — polygenic risk
4. Lipoprotein(a) [Lp(a)] — polygenic risk
5. HDL particle size — polygenic risk
6. LDL particle size — polygenic risk

Lipid metabolism disorders

1. Hyperlipidemia — polygenic risk
2. Hypercholesterolemia — polygenic risk
3. Hypertriglyceridemia — polygenic risk

Individual genetic variants — type: functional variant

1. ELOVL2 rs953413 [long-chain PUFA-related phospholipid trait] — functional variant
2. FADS1 rs174546 [blood lipids; PUFA desaturase locus] — functional variant
3. FADS1/FADS2 locus rs174537 [omega-3/6 fatty acids] — functional variant
4. FADS2 (rs174575) — functional variant
5. ABCA1 R219K (rs2230806) — functional variant
6. CETP TaqIB (rs708272) — functional variant
7. LIPC −514C>T (rs1800588) — functional variant
8. ANGPTL4 E40K (rs116843064) [triglycerides] — functional variant
9. APOA5 S19W (rs3135506) [triglycerides] — functional variant
10. APOA5 −1131T>C (rs662799) [triglycerides] — functional variant
11. GCKR P446L (rs1260326) [triglycerides & metabolic traits] — functional variant
12. LPL S447X (rs328) [triglycerides / HDL] — functional variant
13. APOA2 −265T>C (rs5082) — functional variant
14. APOE ε-haplotype (rs429358 + rs7412) — functional variant
15. PCSK9 R46L (rs11591147) [LDL cholesterol] — functional variant
16. LPA rs10455872 [lipoprotein(a)] — functional variant
17. LPA rs3798220 [lipoprotein(a)] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Omega-6 fatty acids & balance (combined profile) — composite score
2. Fatty acid classes & chain length (combined profile) — composite score
3. Bioactive lipids & related compounds (combined profile) — composite score
4. Cholesterol & triglyceride profile (combined profile) — composite score
5. Apolipoproteins & lipoprotein particles (combined profile) — composite score
6. Lipid disorders (combined risk) — composite score

4.6. Cardiovascular Health

Number of indicators: 46 (39 complex indicators and 7 individual genetic variants).

Complex indicators — type: polygenic risk

Blood pressure and autonomic regulation

1. Systolic blood pressure — polygenic risk
2. Diastolic blood pressure — polygenic risk
3. Hypertension — polygenic risk
4. Hypotension — polygenic risk
5. Resting heart rate — polygenic risk
6. Heart rate variability — polygenic risk

Cardiac electrical conduction

1. PR interval — polygenic risk
2. QRS complex duration — polygenic risk
3. QT interval — polygenic risk
4. Long QT syndrome — polygenic risk
5. Arrhythmia — polygenic risk
6. Atrial fibrillation — polygenic risk
7. Bradycardia — polygenic risk
8. Tachycardia — polygenic risk

Vascular stiffness and subclinical atherosclerosis

1. Arterial stiffness index — polygenic risk
2. Carotid intima-media thickness — polygenic risk
3. Coronary artery calcification — polygenic risk
4. Atherosclerosis — polygenic risk

Cardiomyopathies and inflammatory conditions

1. Cardiomyopathy — polygenic risk
2. Dilated cardiomyopathy — polygenic risk
3. Pericarditis — polygenic risk
4. Rheumatic heart disease — polygenic risk
5. Vasculitis — polygenic risk

Aorta and heart valves

1. Ascending thoracic aorta diameter — polygenic risk
2. Descending thoracic aorta diameter — polygenic risk
3. Aortic aneurysm — polygenic risk
4. Aortic stenosis — polygenic risk
5. Aortic valve calcification — polygenic risk
6. Valvular heart disease — polygenic risk

Cerebrovascular events

1. Stroke — polygenic risk
2. Ischemic stroke — polygenic risk
3. Cerebral aneurysm — polygenic risk

Coronary disease and acute cardiac events

1. Coronary artery disease — polygenic risk
2. Myocardial infarction — polygenic risk
3. Early myocardial infarction — polygenic risk

Cardiac function and circulating biomarkers

1. Left ventricular ejection fraction — polygenic risk
2. Heart failure — polygenic risk
3. N-terminal pro-B-type natriuretic peptide (NT-proBNP) — polygenic risk
4. High-sensitivity cardiac troponin I — polygenic risk

Individual genetic variants — type: functional variant

1. AGT Met268Thr (rs699) [blood pressure] — functional variant
2. AGTR1 A1166C (rs5186) [angiotensin II receptor] — functional variant
3. APOE ε-haplotype (rs429358 + rs7412) — functional variant
4. PCSK9 R46L (rs11591147) [LDL cholesterol] — functional variant
5. IL6R Asp358Ala (rs2228145) [inflammation (IL-6)] — functional variant
6. LPA rs10455872 [lipoprotein(a)] — functional variant
7. LPA rs3798220 [lipoprotein(a)] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Blood pressure & autonomic regulation (combined profile) — composite score
2. Cardiac conduction (combined risk) — composite score
3. Vascular stiffness & subclinical atherosclerosis (combined profile) — composite score
4. Cardiomyopathy & inflammatory conditions (combined risk) — composite score
5. Aorta & cardiac valves (combined profile) — composite score

4.7. Glucose and Metabolic Syndrome

Number of indicators: 51 (36 complex indicators and 15 individual genetic variants).

Complex indicators — type: polygenic risk

Glycemic biomarkers

1. Fasting glucose — polygenic risk
2. Glycated hemoglobin — polygenic risk
3. Glucagon — polygenic risk

Insulin secretion and action

1. Insulin — polygenic risk
2. Proinsulin — polygenic risk
3. HOMA-B (beta-cell function) — polygenic risk
4. Insulin sensitivity — polygenic risk

Spectrum of carbohydrate metabolism disorders

1. Prediabetes — polygenic risk
2. Type 1 diabetes — polygenic risk
3. Type 2 diabetes — polygenic risk

Overall fat mass

1. Body mass index (BMI) — polygenic risk
2. Body fat percentage — polygenic risk
3. Overweight — polygenic risk
4. Obesity — polygenic risk

Body composition (fat and muscle mass)

1. Waist circumference — polygenic risk
2. Hip circumference — polygenic risk
3. Visceral fat — polygenic risk
4. Liver fat fraction — polygenic risk
5. Appendicular lean mass — polygenic risk
6. Body-to-muscle mass ratio — polygenic risk

Adipokines

1. Adiponectin — polygenic risk
2. Leptin — polygenic risk
3. Resistin — polygenic risk

Appetite regulation signals

1. Appetite-regulating hormones — polygenic risk
2. Ghrelin — polygenic risk
3. The leptin receptor — polygenic risk
4. Soluble leptin receptor — polygenic risk
5. Peptide YY — polygenic risk
6. Agouti-related peptide — polygenic risk

Metabolic conditions and urate

1. Metabolic syndrome — polygenic risk
2. Metabolic dysfunction-associated steatotic liver disease (MASLD, also known as fatty liver disease) — polygenic risk
3. Uric acid — polygenic risk
4. Gout — polygenic risk

Diabetic complications

1. Diabetic neuropathy — polygenic risk
2. Diabetic nephropathy — polygenic risk
3. Diabetic retinopathy — polygenic risk

Individual genetic variants — type: functional variant

1. KCNJ11 E23K (rs5219) [type 2 diabetes] — functional variant
2. MTNR1B rs10830963 [glucose / diabetes] — functional variant
3. SLC30A8 R325W (rs13266634) [type 2 diabetes] — functional variant
4. TCF7L2 rs7903146 [type 2 diabetes] — functional variant
5. GCKR P446L (rs1260326) [triglycerides & metabolic traits] — functional variant
6. PPARG Pro12Ala (rs1801282) [type 2 diabetes] — functional variant
7. ADRB3 Trp64Arg (rs4994) — functional variant
8. PLIN1 11482G>A (rs1052700) — functional variant
9. UCP1 −3826A>G (rs1800592) — functional variant
10. UCP2 A55V (rs660339) — functional variant
11. FTO rs9939609 [appetite / body weight] — functional variant
12. MC4R (rs17782313) — functional variant
13. PNPLA3 I148M (rs738409) [MASLD (fatty liver disease)] — functional variant
14. TM6SF2 E167K (rs58542926) [MASLD (fatty liver disease)] — functional variant
15. ABCG2 Q141K (rs2231142) [uric acid / gout] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Insulin secretion & action (combined profile) — composite score
2. Body composition (adiposity & lean mass) (combined profile) — composite score
3. Adipokines (combined profile) — composite score
4. Metabolic states & urates (combined risk) — composite score

4.8. Liver, Gallbladder and Pancreas

Number of indicators: 38 (29 complex indicators and 9 individual genetic variants).

Complex indicators — type: polygenic risk

Liver enzymes and plasma proteins

1. Alanine aminotransferase (ALT) — polygenic risk
2. Aspartate aminotransferase (AST) — polygenic risk
3. Gamma-glutamyl transferase (GGT) — polygenic risk
4. Alkaline phosphatase (ALP) — polygenic risk
5. Bilirubin — polygenic risk
6. Albumin — polygenic risk
7. Liver fat fraction — polygenic risk
8. Liver iron content — polygenic risk

Metabolic liver disease

1. Metabolic dysfunction-associated steatotic liver disease (MASLD, also known as fatty liver disease) — polygenic risk
2. Metabolic dysfunction-associated steatohepatitis (MASH) — polygenic risk
3. Alcohol-related liver disease — polygenic risk

Inflammatory and infectious liver disease

1. Hepatitis B — polygenic risk
2. Hepatitis C — polygenic risk

Fibrosis, cirrhosis and cholestasis

1. Liver fibrosis — polygenic risk
2. Liver cirrhosis — polygenic risk
3. Reduced bile flow — polygenic risk
4. Biliary cholangitis — polygenic risk

Gallbladder and bile duct conditions

1. Gallstone disease — polygenic risk
2. Cholecystitis — polygenic risk
3. Sclerosing cholangitis — polygenic risk

Hepatobiliary cancers

1. Liver cancer — polygenic risk
2. Bile duct cancer — polygenic risk
3. Gallbladder cancer — polygenic risk

Pancreatic function and disease

1. Amylase — polygenic risk
2. Lipase — polygenic risk
3. Pancreatitis — polygenic risk
4. Type 1 diabetes — polygenic risk
5. Type 2 diabetes — polygenic risk
6. Pancreatic cancer — polygenic risk

Individual genetic variants — type: functional variant

1. HFE H63D (rs1799945) [iron overload / hemochromatosis] — functional variant
2. HFE C282Y (rs1800562) [iron overload / hemochromatosis] — functional variant
3. GSTP1 I105V (rs1695) — functional variant
4. NQO1 P187S (rs1800566) — functional variant
5. GCKR P446L (rs1260326) [triglycerides & metabolic traits] — functional variant
6. MBOAT7 rs641738 [hepatic fat / lipid remodeling] — functional variant
7. PNPLA3 I148M (rs738409) [MASLD (fatty liver disease)] — functional variant
8. TM6SF2 E167K (rs58542926) [MASLD (fatty liver disease)] — functional variant
9. ABCG8 D19H (rs11887534) [gallstones] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Liver enzymes & plasma proteins (combined profile) — composite score

4.9. Digestive System Health and Microbiome

Number of indicators: 26 (22 complex indicators and 4 individual genetic variants).

Complex indicators — type: polygenic risk

Esophagus and reflux conditions

1. Esophageal disease — polygenic risk
2. Gastroesophageal reflux disease — polygenic risk
3. Barrett's esophagus — polygenic risk
4. Esophageal cancer — polygenic risk

Stomach and peptic conditions

1. Stomach disease — polygenic risk
2. Gastritis — polygenic risk
3. Peptic ulcer disease — polygenic risk
4. Stomach ulcer — polygenic risk
5. Duodenal ulcer — polygenic risk
6. Stomach polyp — polygenic risk
7. Nausea — polygenic risk

Bowel motility and function

1. Irritable bowel syndrome (IBS) — polygenic risk
2. Stool frequency — polygenic risk
3. Constipation — polygenic risk

Inflammatory bowel disease

1. Crohn's disease — polygenic risk
2. Ulcerative colitis — polygenic risk

Immune-mediated and structural gut conditions

1. Celiac disease — polygenic risk
2. Malabsorption syndrome — polygenic risk
3. Diverticular disease — polygenic risk

Microbiome, microbial exposure and gut barrier

1. Gut microbiome variability — polygenic risk
2. Gut permeability — polygenic risk
3. Helicobacter pylori seropositivity — polygenic risk

Individual genetic variants — type: functional variant

1. MCM6/LCT regulatory -13910C>T (rs4988235) [lactase persistence] — functional variant
2. NOD2 R702W (rs2066844) [inflammatory bowel disease] — functional variant
3. NOD2 G908R (rs2066845) [inflammatory bowel disease] — functional variant
4. FUT2 W143X (rs601338) [secretor status] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Inflammatory bowel diseases (combined risk) — composite score

4.10. Kidneys and Urinary Tract

Number of indicators: 29 (23 complex indicators and 6 individual genetic variants).

Complex indicators — type: polygenic risk

Filtration and nitrogen metabolism

1. Estimated glomerular filtration rate (eGFR) — polygenic risk
2. Serum creatinine — polygenic risk
3. Cystatin C — polygenic risk
4. Serum urea — polygenic risk
5. Albuminuria — polygenic risk
6. Uromodulin — polygenic risk

Electrolytes, minerals and urate

1. Serum sodium — polygenic risk
2. Serum potassium — polygenic risk
3. Chloride — polygenic risk
4. Calcium — polygenic risk
5. Phosphorus — polygenic risk
6. Uric acid — polygenic risk

Glomerular and inflammatory conditions

1. Glomerulonephritis — polygenic risk
2. IgA nephropathy — polygenic risk
3. Nephritis — polygenic risk
4. Nephropathy — polygenic risk
5. Nephrotic syndrome — polygenic risk

Kidney and urinary tract diseases

1. Chronic kidney disease — polygenic risk
2. Kidney failure — polygenic risk
3. Polycystic kidney disease — polygenic risk
4. Kidney stones — polygenic risk
5. Urinary tract infections — polygenic risk
6. Urinary frequency — polygenic risk

Individual genetic variants — type: functional variant

1. SHROOM3 rs17319721 [eGFR / chronic kidney disease] — functional variant
2. UMOD rs12917707 [eGFR / chronic kidney disease] — functional variant
3. UMOD rs4293393 [kidney function] — functional variant
4. CASR A986S (rs1801725) [calcium] — functional variant
5. ABCG2 Q141K (rs2231142) [uric acid / gout] — functional variant
6. SLC2A9 V253I (rs16890979) [uric acid] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Filtration & nitrogen metabolism (combined profile) — composite score
2. Electrolytes, minerals & urates (combined profile) — composite score

4.11. Thyroid, Adrenal and Parathyroid

Number of indicators: 39 (25 complex indicators and 14 individual genetic variants).

Complex indicators — type: polygenic risk

Hormones and quantitative thyroid function

1. Thyroid-stimulating hormone (TSH) — polygenic risk
2. Free thyroxine (T4) — polygenic risk
3. Free triiodothyronine (T3) — polygenic risk
4. Free T3-to-free T4 ratio — polygenic risk

Thyroid disease

1. Thyroid disease (general marker) — polygenic risk
2. Hypothyroidism — polygenic risk
3. Hyperthyroidism — polygenic risk
4. Thyroiditis — polygenic risk
5. Autoimmune thyroid disease — polygenic risk
6. Hashimoto's thyroiditis — polygenic risk
7. Graves' disease — polygenic risk
8. Goiter — polygenic risk
9. Thyroid nodules — polygenic risk
10. Thyroid cancer — polygenic risk

Adrenal hormones and the stress response

1. Morning cortisol — polygenic risk
2. Dehydroepiandrosterone sulfate (DHEA-S) — polygenic risk
3. Aldosterone — polygenic risk
4. Renin or renin activity — polygenic risk
5. Addison's disease — polygenic risk

Parathyroid glands, calcium and phosphate

1. Parathyroid hormone (PTH) — polygenic risk
2. Serum calcium — polygenic risk
3. Serum phosphate — polygenic risk
4. Bone mineral density — polygenic risk
5. Hyperparathyroidism — polygenic risk
6. Hypoparathyroidism — polygenic risk

Individual genetic variants — type: functional variant

1. PDE8B rs4704397 [TSH / thyroid] — functional variant
2. DIO1 rs2235544 [thyroid function] — functional variant
3. DIO2 Thr92Ala (rs225014) [thyroid function] — functional variant
4. CTLA4 rs3087243 [autoimmune thyroid] — functional variant
5. PTPN22 R620W (rs2476601) [autoimmune] — functional variant
6. TSHR rs12101261 [Graves disease susceptibility] — functional variant
7. FOXE1 rs965513 [thyroid] — functional variant
8. NKX2-1/PTCSC3 rs944289 [thyroid cancer] — functional variant
9. HSD11B1 rs12086634 [cortisol] — functional variant
10. NR3C1 rs6198 [cortisol receptor] — functional variant
11. SERPINA6 rs12589136 [cortisol (CBG)] — functional variant
12. CYP11B2 −344C>T (rs1799998) [aldosterone / BP] — functional variant
13. CASR A986S (rs1801725) [calcium] — functional variant
14. CYP24A1 rs6013897 [femoral-neck bone mineral density; vitamin-D pathway] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Thyroid conditions (combined risk) — composite score
2. Parathyroid, calcium & phosphate (combined profile) — composite score

4.12. Reproductive, Growth and Metabolic Hormones

Number of indicators: 30 (22 complex indicators and 8 individual genetic variants).

Complex indicators — type: polygenic risk

Sex and reproductive hormones

1. Luteinising hormone (LH) — polygenic risk
2. Follicle-stimulating hormone (FSH) — polygenic risk
3. Testosterone — polygenic risk
4. Bioavailable testosterone — polygenic risk
5. Oestradiol — polygenic risk
6. Progesterone — polygenic risk
7. 17-hydroxyprogesterone (17-OHP) — polygenic risk
8. DHEA — polygenic risk
9. Pregnenolone — polygenic risk
10. Androgens — polygenic risk
11. Sex hormone-binding globulin (SHBG) — polygenic risk

Pituitary function and the growth axis

1. Insulin-like growth factor 1 (IGF-1) — polygenic risk
2. Prolactin — polygenic risk
3. Oxytocin — polygenic risk

Pancreatic endocrine function and glucose regulation

1. Glycated hemoglobin (HbA1c) — polygenic risk
2. Fasting glucose — polygenic risk
3. Fasting insulin — polygenic risk
4. C-peptide — polygenic risk
5. Insulin resistance — polygenic risk

Appetite hormones and adipokines

1. Ghrelin — polygenic risk
2. Leptin — polygenic risk
3. Adiponectin — polygenic risk

Individual genetic variants — type: functional variant

1. SHBG rs1799941 [SHBG and testosterone concentration] — functional variant
2. IGF1 rs35767 [growth / IGF-1] — functional variant
3. IGF1R rs2229765 [IGF-1 signaling] — functional variant
4. GCK −30G>A (rs1799884) [fasting glucose] — functional variant
5. IRS1 rs2943641 [insulin resistance] — functional variant
6. ADIPOQ rs266729 [adiponectin] — functional variant
7. LEP −2548G>A (rs7799039) [leptin / appetite] — functional variant
8. LEPR Q223R (rs1137101) [leptin receptor] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Sex & reproductive hormones (combined profile) — composite score
2. Pancreatic endocrine & glucose regulation (combined profile) — composite score
3. Appetite-regulating & adipokine hormones (combined profile) — composite score

4.13. Women's Health

Number of indicators: 71 (40 complex indicators and 31 individual genetic variants).

Complex indicators — type: polygenic risk

Reproductive period and ovarian aging

1. Age at menarche — polygenic risk
2. Age at natural menopause — polygenic risk
3. Ovarian insufficiency — polygenic risk
4. Vasomotor menopause symptoms — polygenic risk

Menstrual cycle and bleeding

1. Menstrual cycle length — polygenic risk
2. Heavy menstrual bleeding — polygenic risk

Ovarian conditions and endocrine disorders

1. Polycystic ovary syndrome (PCOS) — polygenic risk
2. Ovarian cyst — polygenic risk
3. Ovarian dysfunction — polygenic risk

Fertility and ovarian reserve

1. Female infertility — polygenic risk
2. Time to pregnancy (fecundability) — polygenic risk
3. Anti-Müllerian hormone (AMH) — polygenic risk

Uterine, cervical and pelvic health

1. Uterine disease — polygenic risk
2. Endometriosis — polygenic risk
3. Uterine fibroids — polygenic risk
4. Pelvic organ prolapse — polygenic risk
5. HPV-associated cervical changes — polygenic risk

Pregnancy complications

1. Gestational diabetes — polygenic risk
2. Preeclampsia — polygenic risk
3. Gestational thrombocytopenia — polygenic risk
4. Preterm birth — polygenic risk
5. Postpartum depression — polygenic risk

Hormonal markers of women's health

1. Follicle-stimulating hormone (FSH) — polygenic risk
2. Luteinising hormone (LH) — polygenic risk
3. Oestradiol — polygenic risk
4. Progesterone — polygenic risk
5. Testosterone — polygenic risk
6. Bioavailable testosterone — polygenic risk
7. DHEA — polygenic risk
8. Pregnenolone — polygenic risk
9. Sex hormone-binding globulin (SHBG) — polygenic risk
10. Oestrogen metabolism — polygenic risk

Predisposition to breast cancer and gynecological cancers

1. Mammographic breast density — polygenic risk
2. Breast cancer — polygenic risk
3. Ovarian cancer — polygenic risk
4. Endometrial cancer — polygenic risk
5. Cervical cancer — polygenic risk

Bone health in the context of menopause

1. Bone mineral density — polygenic risk
2. Osteoporosis — polygenic risk
3. Fractures — polygenic risk

Individual genetic variants — type: functional variant

1. LIN28B rs314276 [age at menarche] — functional variant
2. BRSK1 rs1172822 [menopause / ovarian reserve] — functional variant
3. HELB rs75770066 [menopause / ovarian reserve] — functional variant
4. MCM8 E341K (rs16991615) [menopause / ovarian reserve] — functional variant
5. FSHB rs10835638 [reproductive hormones] — functional variant
6. FSHB rs11031006 [reproductive hormones] — functional variant
7. DENND1A rs2479106 [PMOS (polycystic ovary syndrome)] — functional variant
8. FSHR rs2268361 [PMOS (PCOS) susceptibility locus] — functional variant
9. LHCGR rs13405728 [PMOS (PCOS) susceptibility locus] — functional variant
10. THADA rs13429458 [PMOS (polycystic ovary syndrome)] — functional variant
11. GREB1 rs13394619 [endometriosis] — functional variant
12. WNT4 rs7521902 [endometriosis] — functional variant
13. BET1L rs2280543 [uterine fibroids] — functional variant
14. TNRC6B rs12484776 [uterine fibroids / body-shape locus] — functional variant
15. TERT rs2736100 [telomere / cancer] — functional variant
16. TCF7L2 rs7903146 [type 2 diabetes] — functional variant
17. FLT1-region rs4769613 [preeclampsia] — functional variant
18. F2 G20210A (rs1799963) [thrombophilia] — functional variant
19. F5 Leiden (rs6025) [thrombophilia] — functional variant
20. ESR1 PvuII (rs2234693) [estrogen receptor] — functional variant
21. ESR1 XbaI (rs9340799) [estrogen receptor] — functional variant
22. COMT Val158Met (rs4680) [estrogen / dopamine] — functional variant
23. CYP19A1 rs10046 [estrogen (aromatase)] — functional variant
24. CYP1B1 Leu432Val (rs1056836) [estrogen metabolism] — functional variant
25. BRCA1 (rs80357906) [hereditary breast/ovarian cancer] — functional variant
26. BRCA1 (rs80357914) [hereditary breast/ovarian cancer] — functional variant
27. BRCA2 (rs80359550) [hereditary breast/ovarian cancer] — functional variant
28. CHEK2 I157T (rs17879961) [breast cancer risk] — functional variant
29. FGFR2 rs2981582 [breast cancer] — functional variant
30. TOX3 rs3803662 [breast cancer] — functional variant
31. BNC2 (9p22) rs3814113 [ovarian cancer] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Uterine, cervical & pelvic health (combined risk) — composite score
2. Female hormone biomarkers (combined profile) — composite score

4.14. Men's Health

Number of indicators: 34 (22 complex indicators and 12 individual genetic variants).

Complex indicators — type: polygenic risk

Male fertility and sperm quality

1. Testicular disease — polygenic risk

Sexual function

1. Erectile dysfunction — polygenic risk
2. Sexual dysfunction — polygenic risk
3. Sexual activity — polygenic risk

Prostate and lower urinary tract health

1. Prostate disease — polygenic risk
2. Benign prostatic hyperplasia with lower urinary tract symptoms — polygenic risk
3. Prostatitis — polygenic risk
4. Chronic prostatitis (chronic pelvic pain syndrome) — polygenic risk
5. Prostate-specific antigen (PSA) — polygenic risk

Hormonal markers and androgen status

1. Luteinising hormone (LH) — polygenic risk
2. Follicle-stimulating hormone (FSH) — polygenic risk
3. Testosterone — polygenic risk
4. Bioavailable testosterone — polygenic risk
5. Oestradiol — polygenic risk
6. DHEA — polygenic risk
7. Sex hormone-binding globulin (SHBG) — polygenic risk
8. Male hypogonadism — polygenic risk

Age-related and androgen-dependent male traits

1. Androgenetic alopecia in men — polygenic risk
2. Facial and body hair growth — polygenic risk
3. Timing of puberty in men — polygenic risk

Cancer risks in men's health

1. Prostate cancer — polygenic risk
2. Testicular germ cell tumor — polygenic risk

Individual genetic variants — type: functional variant

1. FSHR Asn680Ser (rs6166) [reproductive hormones] — functional variant
2. NOS3 Glu298Asp (rs1799983) [erectile function] — functional variant
3. KLK3 I179T (rs17632542) [PSA / prostate] — functional variant
4. KLK3 region rs2735839 [prostate cancer / PSA level] — functional variant
5. KLK3 rs61752561 [PSA / prostate] — functional variant
6. AR rs6152 [androgen receptor] — functional variant
7. SRD5A2-region rs112881196 [androgens / hair] — functional variant
8. SRD5A2 V89L (rs523349) [androgens (DHT)] — functional variant
9. SPOCK1 rs1073917 [androgen-related] — functional variant
10. BRCA2 (rs80359550) [hereditary breast/ovarian cancer] — functional variant
11. HOXB13 G84E (rs138213197) [prostate cancer] — functional variant
12. MSMB rs10993994 [prostate cancer] — functional variant

4.15. Cancer Risks

Number of indicators: 55 (35 complex indicators and 20 individual genetic variants).

Complex indicators — type: polygenic risk

Skin cancers

1. Basal cell carcinoma — polygenic risk
2. Squamous cell carcinoma of the skin — polygenic risk
3. Melanoma — polygenic risk

Genitourinary cancers

1. Bladder cancer — polygenic risk
2. Kidney cancer — polygenic risk

Digestive tract cancers

1. Colorectal cancer — polygenic risk
2. Colon cancer — polygenic risk
3. Rectal cancer — polygenic risk
4. Stomach cancer — polygenic risk
5. Esophageal cancer — polygenic risk

Hepatobiliary cancers and pancreatic cancer

1. Pancreatic cancer — polygenic risk
2. Liver cancer — polygenic risk
3. Bile duct cancer — polygenic risk
4. Gallbladder cancer — polygenic risk

Respiratory system cancers

1. Lung cancer — polygenic risk
2. Lung adenocarcinoma — polygenic risk
3. Non-small cell lung cancer — polygenic risk

Hematologic malignancies

1. Leukemia — polygenic risk
2. Hodgkin lymphoma — polygenic risk
3. Non-Hodgkin lymphoma — polygenic risk
4. Multiple myeloma — polygenic risk

Central nervous system and eye tumors

1. Glioma — polygenic risk
2. Glioblastoma — polygenic risk
3. Oligodendroglioma — polygenic risk
4. Meningioma — polygenic risk
5. Neuroblastoma — polygenic risk
6. Eye cancer — polygenic risk

Endocrine and neuroendocrine tumors

1. Thyroid cancer — polygenic risk
2. Neuroendocrine tumor — polygenic risk

Bone and soft tissue cancers

1. Bone cancer (osteosarcoma) — polygenic risk
2. Sarcoma — polygenic risk

Head, neck and upper digestive tract cancers

1. Head and neck cancer — polygenic risk
2. Oral cancer — polygenic risk
3. Oropharyngeal cancer — polygenic risk
4. Pharyngeal cancer — polygenic risk

Individual genetic variants — type: functional variant

1. MC1R R151C (rs1805007) [skin/hair pigmentation] — functional variant
2. MC1R R160W (rs1805008) [skin/hair pigmentation] — functional variant
3. TERT rs2736100 [telomere / cancer] — functional variant
4. NAT2 rs1495741 [carcinogen detox / bladder] — functional variant
5. TERT rs2736098 [telomerase locus; prostate and other cancers] — functional variant
6. 8q24 rs6983267 [colorectal / prostate cancer] — functional variant
7. APC I1307K (rs1801155) [colorectal cancer] — functional variant
8. MUTYH Y179C (rs34612342) [colorectal polyposis] — functional variant
9. MUTYH G396D (rs36053993) [colorectal polyposis] — functional variant
10. SMAD7 rs4939827 [colorectal cancer] — functional variant
11. PSCA rs2294008 [gastric cancer] — functional variant
12. PSCA rs2976392 [diffuse-type gastric cancer] — functional variant
13. BRCA1 (rs80357906) [hereditary breast/ovarian cancer] — functional variant
14. BRCA1 (rs80357914) [hereditary breast/ovarian cancer] — functional variant
15. BRCA2 (rs80359550) [hereditary breast/ovarian cancer] — functional variant
16. CHEK2 I157T (rs17879961) [breast cancer risk] — functional variant
17. EPAS1 rs11894252 [hypoxia / cancer] — functional variant
18. NR5A2 rs3790844 [pancreatic cancer] — functional variant
19. CHRNA5 D398N (rs16969968) [nicotine dependence] — functional variant
20. FOXE1 rs965513 [thyroid] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Skin cancers (combined risk) — composite score
2. Central nervous system & eye tumors (combined risk) — composite score

4.16. Allergies and Intolerances

Number of indicators: 28 (17 complex indicators and 11 individual genetic variants).

Complex indicators — type: polygenic risk

General allergic predisposition and biomarkers

1. Allergic sensitization — polygenic risk
2. Total serum immunoglobulin E (IgE) — polygenic risk
3. Food allergy — polygenic risk
4. Eosinophil count — polygenic risk

Respiratory and inhalant allergies

1. Allergic rhinitis — polygenic risk
2. Asthma — polygenic risk
3. Sensitization to animal allergens — polygenic risk
4. Cat allergy — polygenic risk
5. Dog allergy — polygenic risk

Food intolerances and immune-mediated reactions

1. Lactase persistence — polygenic risk
2. Fructose metabolism and absorption — polygenic risk
3. Celiac disease — polygenic risk
4. Peanut allergy — polygenic risk
5. Egg allergy — polygenic risk

Skin and contact allergies

1. Atopic dermatitis — polygenic risk
2. Allergic contact dermatitis — polygenic risk
3. Angioedema — polygenic risk

Individual genetic variants — type: functional variant

1. IL13 rs1800925 [atopic dermatitis / skin barrier] — functional variant
2. TSLP rs1837253 [asthma / allergy] — functional variant
3. FCER1A rs2251746 [IgE / allergy] — functional variant
4. IL13 rs20541 [allergy / IgE] — functional variant
5. IL4R rs1801275 [allergy / IgE] — functional variant
6. MCM6/LCT regulatory -13910C>T (rs4988235) [lactase persistence] — functional variant
7. SERPINB cluster rs12964116 [food allergy] — functional variant
8. AOC1 rs10156191 [histamine metabolism] — functional variant
9. AOC1 rs1049742 [histamine metabolism] — functional variant
10. AOC1 rs2052129 [histamine metabolism] — functional variant
11. HNMT rs11558538 [histamine metabolism] — functional variant

4.17. Immunity, Infections and Autoimmune Conditions

Number of indicators: 57 (41 complex indicators and 16 individual genetic variants).

Complex indicators — type: polygenic risk

Systemic autoimmune conditions

1. Autoimmune disease (general marker) — polygenic risk
2. Systemic autoimmune connective tissue disease — polygenic risk
3. Systemic lupus erythematosus — polygenic risk
4. Rheumatoid arthritis — polygenic risk
5. Systemic sclerosis — polygenic risk
6. Sjögren's syndrome — polygenic risk
7. Behçet's disease — polygenic risk
8. Sarcoidosis — polygenic risk
9. Antiphospholipid syndrome — polygenic risk

Organ-specific autoimmune conditions

1. Type 1 diabetes — polygenic risk
2. Autoimmune thyroid disease — polygenic risk
3. Graves' disease — polygenic risk
4. Celiac disease — polygenic risk
5. Multiple sclerosis — polygenic risk
6. Myasthenia gravis — polygenic risk
7. Biliary cholangitis — polygenic risk
8. Sclerosing cholangitis — polygenic risk

Inflammatory bowel disease

1. Crohn's disease — polygenic risk
2. Ulcerative colitis — polygenic risk

Immune-mediated skin and joint conditions

1. Psoriasis — polygenic risk
2. Psoriatic arthritis — polygenic risk
3. Atopic dermatitis — polygenic risk
4. Ankylosing spondylitis — polygenic risk

Bacterial and urinary infections

1. Tuberculosis — polygenic risk
2. Pneumonia — polygenic risk
3. Meningitis — polygenic risk
4. Urinary tract infections — polygenic risk
5. Clostridioides difficile infection — polygenic risk

Viral infections and severity of illness

1. Hepatitis B — polygenic risk
2. Hepatitis C — polygenic risk
3. Shingles — polygenic risk
4. HIV infection and AIDS progression — polygenic risk
5. Mumps — polygenic risk
6. Severe COVID-19 — polygenic risk

Other infections and debated phenotypes

1. Lyme disease — polygenic risk

Immune and inflammatory biomarkers

1. Neutrophil count — polygenic risk
2. Monocyte count — polygenic risk
3. Eosinophil count — polygenic risk
4. Basophil count — polygenic risk
5. Total serum immunoglobulin E (IgE) — polygenic risk
6. C-reactive protein — polygenic risk

Individual genetic variants — type: functional variant

1. CTLA4 rs3087243 [autoimmune thyroid] — functional variant
2. PTPN22 R620W (rs2476601) [autoimmune] — functional variant
3. STAT4 rs7574865 [autoimmune] — functional variant
4. TNFAIP3 rs2230926 [autoimmune] — functional variant
5. IL2RA rs2104286 [autoimmune] — functional variant
6. IL7R rs6897932 [multiple sclerosis / autoimmune] — functional variant
7. ATG16L1 T300A (rs2241880) [Crohn’s disease] — functional variant
8. IL23R R381Q (rs11209026) [psoriasis / IBD] — functional variant
9. NOD2 R702W (rs2066844) [inflammatory bowel disease] — functional variant
10. NOD2 G908R (rs2066845) [inflammatory bowel disease] — functional variant
11. TRAF3IP2 rs33980500 [psoriasis] — functional variant
12. FCGR2A His167Arg (rs1801274) [ulcerative colitis / IBD] — functional variant
13. TLR4 Asp299Gly (rs4986790) [innate immune receptor; curated] — functional variant
14. DPP9 rs2109069 [severe COVID-19] — functional variant
15. LZTFL1 locus rs73064425 [severe COVID-19] — functional variant
16. OAS1 rs10774671 [severe COVID-19] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Systemic autoimmune conditions (combined risk) — composite score
2. Organ-specific autoimmune conditions (combined risk) — composite score
3. Immune-mediated skin & joint conditions (combined risk) — composite score
4. Immune and inflammatory biomarkers (combined profile) — composite score

4.18. Respiratory System Health

Number of indicators: 22 (16 complex indicators and 6 individual genetic variants).

Complex indicators — type: polygenic risk

Lung function

1. Forced expiratory volume in one second (FEV₁) — polygenic risk
2. Forced vital capacity (FVC) — polygenic risk
3. FEV₁/FVC ratio — polygenic risk
4. Peak expiratory flow — polygenic risk

Lower airway conditions

1. Asthma — polygenic risk
2. Chronic obstructive pulmonary disease (COPD) — polygenic risk
3. Chronic bronchitis — polygenic risk
4. Chronic mucus hypersecretion — polygenic risk

Upper airways and sinuses

1. Allergic rhinitis — polygenic risk
2. Chronic rhinosinusitis — polygenic risk
3. Nasal polyps — polygenic risk
4. Sinus congestion — polygenic risk

Interstitial, infectious and sleep-related respiratory conditions

1. Pneumonia — polygenic risk
2. Obstructive sleep apnea — polygenic risk
3. Interstitial lung disease — polygenic risk
4. Idiopathic pulmonary fibrosis — polygenic risk

Individual genetic variants — type: functional variant

1. CHRNA3 rs1051730 [nicotine / lung] — functional variant
2. FAM13A rs7671167 [COPD / lung function] — functional variant
3. HHIP rs13118928 [COPD / lung function] — functional variant
4. GSDMB rs7216389 [asthma] — functional variant
5. IL33 rs1342326 [asthma] — functional variant
6. MUC5B rs35705950 [pulmonary fibrosis] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Lower-airway conditions (combined risk) — composite score

4.19. Mental Health and Personality

Number of indicators: 39 (38 complex indicators and 1 individual genetic variant).

Complex indicators — type: polygenic risk

Affective and psychotic conditions

1. Depression — polygenic risk
2. Bipolar disorder — polygenic risk
3. Mania — polygenic risk
4. Mood instability — polygenic risk
5. Schizophrenia — polygenic risk
6. Psychosis — polygenic risk

Anxiety and traumatic stress

1. Anxiety — polygenic risk
2. Panic attacks — polygenic risk
3. Social anxiety — polygenic risk
4. Worry proneness — polygenic risk
5. Post-traumatic stress disorder (PTSD) — polygenic risk

Obsessive-compulsive spectrum

1. Obsessive-compulsive disorder (OCD) — polygenic risk
2. Hoarding symptoms — polygenic risk

Personality disorders

1. Antisocial personality disorder — polygenic risk
2. Borderline personality disorder — polygenic risk
3. Personality disorder — polygenic risk

Emotional reactivity

1. Anger — polygenic risk
2. Irritability — polygenic risk
3. Nervousness — polygenic risk

Predisposition to self-harm

1. Self-harm — polygenic risk
2. Suicidal ideation — polygenic risk
3. Suicide attempts — polygenic risk
4. Social interaction — polygenic risk

Selected Big Five traits

1. Conscientiousness — polygenic risk
2. Extraversion — polygenic risk
3. Neuroticism — polygenic risk

Creativity and social functioning

1. Creativity — polygenic risk
2. Loneliness — polygenic risk
3. Social interaction — polygenic risk

Positive psychological well-being

1. Subjective well-being — polygenic risk
2. Life satisfaction — polygenic risk
3. Positive affect — polygenic risk
4. Optimism — polygenic risk

Risk-taking predisposition

1. Boldness in decision-making — polygenic risk
2. Self-reported risky decisions — polygenic risk
3. Adventurousness — polygenic risk

Neurotransmitter signaling

1. Dopamine — polygenic risk
2. Serotonin — polygenic risk

Individual genetic variants — type: functional variant

1. BDNF Val66Met (rs6265) [neurotrophin; BMI and behavioral traits] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Mood & psychotic disorders (combined risk) — composite score

4.20. Sleep and Circadian Rhythms

Number of indicators: 26 (18 complex indicators and 8 individual genetic variants).

Complex indicators — type: polygenic risk

Sleep duration and timing

1. Sleep duration — polygenic risk

Sleep quality and architecture

1. Sleep quality — polygenic risk
2. Sleep latency — polygenic risk
3. Sleep depth — polygenic risk
4. NREM sleep duration — polygenic risk
5. REM sleep duration — polygenic risk

Sleep continuity and fragmentation

1. Wake after sleep onset — polygenic risk

Sleep disturbances

1. Insomnia — polygenic risk
2. Obstructive sleep apnea — polygenic risk
3. Snoring — polygenic risk
4. Restless legs syndrome — polygenic risk
5. Movement during sleep — polygenic risk
6. REM sleep behavior disorder — polygenic risk
7. Sleepwalking (somnambulism) — polygenic risk

Circadian features and daytime sleep

1. Chronotype — polygenic risk
2. Daytime sleepiness — polygenic risk
3. Daytime napping — polygenic risk
4. Caffeine-related sleep disturbance — polygenic risk

Individual genetic variants — type: functional variant

1. ADA rs73598374 [sleep depth] — functional variant
2. ADORA2A rs5751876 [caffeine / sleep] — functional variant
3. MEIS1 rs113851554 [restless legs] — functional variant
4. CLOCK 3111T>C (rs1801260) [circadian rhythm] — functional variant
5. PAX8-region / LINC02966 rs62158211 [sleep duration] — functional variant
6. RGS16 H137R (rs1144566) [chronotype] — functional variant
7. RGS16-region rs12736689 [chronotype] — functional variant
8. VIP-region rs9479402 [chronotype] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Sleep quality & architecture (combined profile) — composite score
2. Circadian rhythm & daytime sleep (combined profile) — composite score

4.21. Addictions and Behavior

Number of indicators: 33 (25 complex indicators and 8 individual genetic variants).

Complex indicators — type: polygenic risk

Alcohol consumption and physiological response

1. Alcohol consumption — polygenic risk
2. Number of alcoholic drinks per week — polygenic risk

Smoking and nicotine behavior

1. Smoking — polygenic risk
2. Onset of regular smoking — polygenic risk
3. Cigarettes per day — polygenic risk
4. Likelihood of quitting smoking — polygenic risk
5. Nicotine and alcohol co-dependence — polygenic risk

Cannabis and other psychoactive substances

1. Substance use disorder — polygenic risk
2. Cannabis dependence — polygenic risk

Addictions and risk-taking behavior

1. Addiction (general marker) — polygenic risk
2. Internet addiction — polygenic risk
3. Risk-taking behavior — polygenic risk

Consumption behavior and lifestyle

1. Caffeine consumption — polygenic risk
2. Sedentary work pattern — polygenic risk

Eating disorders

1. Eating disorders — polygenic risk
2. Anorexia nervosa — polygenic risk
3. Bulimia nervosa — polygenic risk
4. Binge eating — polygenic risk

Macronutrient intake and eating habits

1. Carbohydrate intake — polygenic risk
2. Sugar intake — polygenic risk
3. Sweet cravings — polygenic risk
4. Fatty food intake — polygenic risk

Chemosensory perception (taste and smell)

1. Bitter taste — polygenic risk
2. Sweet taste — polygenic risk
3. Sense of smell — polygenic risk

Individual genetic variants — type: functional variant

1. ADH1B Arg48His (rs1229984) [alcohol metabolism] — functional variant
2. ALDH2 Glu504Lys (rs671) [alcohol metabolism] — functional variant
3. CHRNA5 D398N (rs16969968) [nicotine dependence] — functional variant
4. CYP1A2 rs762551 [caffeine metabolism] — functional variant
5. TAS2R38 PAV/AVI haplotype [bitter taste] — functional variant
6. TAS2R38 I296V (rs10246939) [bitter taste] — functional variant
7. TAS2R38 V262A (rs1726866) [bitter taste] — functional variant
8. TAS2R38 A49P (rs713598) [bitter taste] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Smoking & nicotine behavior (combined profile) — composite score

4.22. Eye and Ear Health

Number of indicators: 42 (35 complex indicators and 7 individual genetic variants).

Complex indicators — type: polygenic risk

Refraction and eye shape

1. Refractive error — polygenic risk
2. Nearsightedness — polygenic risk
3. Farsightedness — polygenic risk
4. Astigmatism — polygenic risk
5. Corneal astigmatism — polygenic risk
6. Axial eye length — polygenic risk

Anterior segment and intraocular pressure

1. Intraocular pressure — polygenic risk
2. Glaucoma — polygenic risk
3. Central corneal thickness — polygenic risk
4. Corneal hysteresis — polygenic risk
5. Keratoconus — polygenic risk
6. Cataracts — polygenic risk
7. Conjunctivitis — polygenic risk
8. Dry eye disease — polygenic risk
9. Eye inflammation — polygenic risk
10. Uveitis — polygenic risk

Retina and optic nerve

1. Age-related macular degeneration (AMD) — polygenic risk
2. Diabetic retinopathy — polygenic risk
3. Retinal nerve fiber layer thickness — polygenic risk
4. Ganglion cell and inner plexiform layer thickness — polygenic risk
5. Retinal vessel caliber — polygenic risk
6. Retinal vessel fractal density — polygenic risk

Visual function and other eye conditions

1. Eye disease — polygenic risk
2. Visual acuity — polygenic risk
3. Contrast sensitivity — polygenic risk
4. Pseudoexfoliation syndrome — polygenic risk
5. Exfoliative glaucoma — polygenic risk

Hearing and auditory function

1. Hearing loss — polygenic risk
2. Age-related hearing decline in adulthood — polygenic risk
3. Difficulty hearing in background noise — polygenic risk

Inner ear and balance disorders

1. Tinnitus — polygenic risk
2. Vertigo (benign paroxysmal positional vertigo, BPPV) — polygenic risk
3. Ménière's disease — polygenic risk

Middle and outer ear

1. Middle ear disease (otitis media) — polygenic risk
2. Otosclerosis — polygenic risk

Individual genetic variants — type: functional variant

1. SIX6 His141Asn (rs33912345) [glaucoma / intraocular pressure] — functional variant
2. LOXL1 R141L (rs1048661) [exfoliation glaucoma] — functional variant
3. LOXL1 G153D (rs3825942) [exfoliation glaucoma] — functional variant
4. ARMS2 A69S (rs10490924) [macular degeneration] — functional variant
5. CFH Y402H (rs1061170) [macular degeneration] — functional variant
6. HTRA1 rs11200638 [age-related macular degeneration] — functional variant
7. ABCC11 Gly180Arg (rs17822931) [earwax type / axillary odor] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Refraction & ocular shape (combined risk) — composite score
2. Anterior segment & intraocular pressure (combined risk) — composite score
3. Retina & optic nerve (combined profile) — composite score

4.23. Dental and Oral Health

Number of indicators: 35 (29 complex indicators and 6 individual genetic variants).

Complex indicators — type: polygenic risk

Teeth: development, cavities and enamel

1. Cavities — polygenic risk
2. Enamel hypoplasia — polygenic risk
3. Number of teeth in adulthood — polygenic risk
4. Timing of baby tooth eruption — polygenic risk
5. Number of baby teeth — polygenic risk

Gums, periodontium and oral microbiome

1. Gum disease — polygenic risk
2. Periodontitis — polygenic risk
3. A combined genetic score for periodontitis and tooth mobility (MTAG) — polygenic risk
4. Average clinical attachment loss — polygenic risk
5. Bleeding gums — polygenic risk
6. Composition of the oral microbiome — polygenic risk

Jaw, bite and orofacial pain

1. Temporomandibular joint pain disorder — polygenic risk
2. Chronic pain — polygenic risk
3. Migraine — polygenic risk

Oral and pharyngeal cancers

1. Oral cancer — polygenic risk
2. Oropharyngeal cancer — polygenic risk
3. Pharyngeal cancer — polygenic risk

Nutrients related to dental and gum tissue

1. Vitamin D (25(OH)D) — polygenic risk
2. Phylloquinone (vitamin K1) — polygenic risk
3. Vitamin C — polygenic risk
4. Folate (vitamin B9) — polygenic risk
5. Calcium — polygenic risk
6. Phosphorus — polygenic risk
7. Magnesium — polygenic risk
8. Zinc — polygenic risk
9. Iron — polygenic risk

Systemic links to oral health

1. Bone density — polygenic risk
2. Rheumatoid arthritis — polygenic risk
3. Sjögren's syndrome — polygenic risk

Individual genetic variants — type: functional variant

1. CACNB2 rs10740993 [primary tooth eruption] — functional variant
2. KCNJ2 rs8080944 [primary tooth eruption] — functional variant
3. IL1A rs1800587 [periodontitis] — functional variant
4. IL1B rs1143634 [periodontitis] — functional variant
5. MMP3 rs679620 [periodontitis] — functional variant
6. FUT2 W143X (rs601338) [secretor status] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Nutrients linked to teeth & gums (combined profile) — composite score

4.24. Skin, Hair and Appearance

Number of indicators: 51 (36 complex indicators and 15 individual genetic variants).

Complex indicators — type: polygenic risk

Structure and visible skin aging

1. Skin aging — polygenic risk
2. Facial photoaging — polygenic risk
3. Skin elasticity — polygenic risk
4. Skin hydration — polygenic risk

Circulating matrix proteins and growth factors

1. Decorin — polygenic risk
2. Fibronectin — polygenic risk
3. Laminin — polygenic risk
4. Epidermal growth factor — polygenic risk

Barrier, dryness and skin sensitivity

1. Skin barrier function — polygenic risk
2. Filaggrin-dependent skin barrier homeostasis — polygenic risk
3. Dry skin — polygenic risk
4. Skin sensitivity to sunlight — polygenic risk

Pigmentation, sun response and moles

1. Facial skin pigmentation — polygenic risk
2. Tanning response — polygenic risk
3. Freckles — polygenic risk
4. Melanocytic nevi — polygenic risk

Acne, pores and pilosebaceous unit health

1. Pilosebaceous unit disorders — polygenic risk
2. Acne — polygenic risk
3. Rosacea — polygenic risk
4. Vascular skin disorders — polygenic risk

Inflammatory, allergic and infectious skin conditions

1. Skin disease — polygenic risk
2. Atopic dermatitis — polygenic risk
3. Eczema — polygenic risk
4. Hand eczema — polygenic risk
5. Psoriasis — polygenic risk
6. Allergic contact dermatitis — polygenic risk
7. Dermatophytosis — polygenic risk
8. Dermatomyositis — polygenic risk

Hair growth, thickness and loss

1. Hair thickness — polygenic risk
2. Hair graying — polygenic risk
3. Facial and body hair growth — polygenic risk
4. Alopecia areata — polygenic risk

Skin cancer risks

1. Skin cancer — polygenic risk
2. Melanoma — polygenic risk
3. Basal cell carcinoma — polygenic risk
4. Squamous cell carcinoma of the skin — polygenic risk

Individual genetic variants — type: functional variant

1. COL1A1 rs1800012 [bone / connective tissue] — functional variant
2. ELN rs2071307 [skin elastin] — functional variant
3. ASIP-region rs4911414 [pigmentation] — functional variant
4. HERC2/OCA2 rs12913832 [eye/hair color] — functional variant
5. MC1R R151C (rs1805007) [skin/hair pigmentation] — functional variant
6. MC1R R160W (rs1805008) [skin/hair pigmentation] — functional variant
7. SLC24A5 A111T (rs1426654) [skin pigmentation] — functional variant
8. SLC45A2 L374F (rs16891982) [pigmentation] — functional variant
9. TYR S192Y (rs1042602) [pigmentation] — functional variant
10. MC1R Asp294His (rs1805009) [melanoma / UV sensitivity] — functional variant
11. IRF4 rs12203592 [pigmentation / greying] — functional variant
12. IL13 rs20541 [allergy / IgE] — functional variant
13. IL23R R381Q (rs11209026) [psoriasis / IBD] — functional variant
14. SRD5A2-region rs112881196 [androgens / hair] — functional variant
15. MITF E318K (rs149617956) [melanoma] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Inflammatory, allergic & infectious skin conditions (combined risk) — composite score

4.25. Musculoskeletal System, Injury and Recovery

Number of indicators: 37 (22 complex indicators and 15 individual genetic variants).

Complex indicators — type: polygenic risk

Muscle mass and function

1. Muscle strength — polygenic risk
2. Muscle volume — polygenic risk
3. Appendicular lean mass — polygenic risk
4. Thigh muscle fat infiltration — polygenic risk
5. Muscle mass loss — polygenic risk
6. Sarcopenia — polygenic risk

Bone density and fracture risk

1. Bone mineral density — polygenic risk
2. Osteoporosis — polygenic risk
3. Fractures — polygenic risk

Joint health

1. Osteoarthritis — polygenic risk
2. Joint pain — polygenic risk
3. Joint stiffness — polygenic risk
4. Knee pain — polygenic risk
5. Adhesive capsulitis of the shoulder — polygenic risk

Spine and back health

1. Lumbar intervertebral disc degeneration — polygenic risk
2. Lumbar disc herniation — polygenic risk
3. Lumbar spinal stenosis — polygenic risk

Tendons, ligaments and tunnel syndromes

1. Tendinopathy — polygenic risk
2. Achilles tendon injury — polygenic risk
3. Ankle injury — polygenic risk
4. Dupuytren's contracture — polygenic risk
5. Carpal tunnel syndrome — polygenic risk

Individual genetic variants — type: functional variant

1. LRP5 rs3736228 [bone density] — functional variant
2. VDR rs1544410 [vitamin D] — functional variant
3. VDR FokI (rs2228570) [vitamin D] — functional variant
4. VDR rs7975232 [vitamin D] — functional variant
5. WNT16 rs2707466 [bone density] — functional variant
6. WNT16 rs2908004 [bone density] — functional variant
7. GDF5 rs143383 [osteoarthritis / joints] — functional variant
8. GDF5 rs143384 [osteoarthritis / joints] — functional variant
9. TGFA rs958685 [joint / cleft] — functional variant
10. COL1A1 rs1107946 [bone / connective tissue] — functional variant
11. COL1A1 rs1800012 [bone / connective tissue] — functional variant
12. COL5A1 rs12722 [tendon / ligament] — functional variant
13. TNC rs1138545 [tendon] — functional variant
14. TNC rs7021589 [tendon] — functional variant
15. TNC rs72758637 [tendon] — functional variant

4.26. Athletic Potential and Physical Performance

Number of indicators: 25 (13 complex indicators and 12 individual genetic variants).

Complex indicators — type: polygenic risk

Aerobic capacity and recovery

1. Cardiorespiratory endurance (VO₂max) — polygenic risk
2. Heart rate response to exercise — polygenic risk
3. Heart-rate recovery after exercise — polygenic risk
4. Resting heart rate — polygenic risk
5. Heart rate variability — polygenic risk

Strength and body composition

1. Muscle fiber type — polygenic risk

Exercise biomarkers

1. Lactate — polygenic risk
2. Creatine — polygenic risk
3. Serum creatine kinase — polygenic risk

Physical activity patterns

1. Physical activity — polygenic risk
2. Usual walking pace — polygenic risk

Reaction and information-processing speed

1. Reaction time — polygenic risk
2. Information-processing speed — polygenic risk

Individual genetic variants — type: functional variant

1. ACE I/D (rs1799752) [endurance] — functional variant
2. PPARA rs4253778 [lipid oxidation / endurance] — functional variant
3. PPARGC1A rs8192678 [mitochondrial / endurance] — functional variant
4. ACTN3 R577X (rs1815739) [muscle fiber / sprint] — functional variant
5. AMPD1 rs17602729 [muscle energy metabolism] — functional variant
6. GCKR P446L (rs1260326) [triglycerides & metabolic traits] — functional variant
7. SLC16A1/MCT1 rs1049434 [lactate transport] — functional variant
8. CKM rs8111989 [muscle creatine kinase] — functional variant
9. UCP3 −55C>T (rs1800849) — functional variant
10. ADRB2 rs1042713 [bronchi / metabolism] — functional variant
11. ADRB2 rs1042714 [bronchi / metabolism] — functional variant
12. PPP1R3B rs9987289 [glycogen metabolism] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Aerobic capacity & recovery (combined profile) — composite score

4.27. Longevity and Biological Aging

Number of indicators: 53 (35 complex indicators and 18 individual genetic variants).

Complex indicators — type: polygenic risk

Lifespan, healthspan and integrated aging

1. Exceptional longevity — polygenic risk
2. Healthspan — polygenic risk
3. Pace of aging — polygenic risk

Molecular and cellular aging

1. Telomere length — polygenic risk
2. Epigenetic age acceleration — polygenic risk
3. The Klotho protein — polygenic risk
4. Catalase — polygenic risk
5. Superoxide dismutase activity — polygenic risk
6. Thioredoxin — polygenic risk

Physical vulnerability, mobility and resilience

1. Frailty index — polygenic risk
2. Muscle mass loss — polygenic risk
3. Sarcopenia — polygenic risk
4. Reduced grip strength in older age — polygenic risk
5. Usual walking pace — polygenic risk
6. Physical activity — polygenic risk
7. Orthostatic hypotension — polygenic risk

Brain and cognitive aging

1. Cognitive decline — polygenic risk
2. Episodic memory — polygenic risk
3. Short-term memory — polygenic risk
4. Processing speed — polygenic risk
5. Reaction time — polygenic risk
6. Dementia — polygenic risk
7. Alzheimer's disease — polygenic risk
8. Frontotemporal dementia — polygenic risk
9. Dementia with Lewy bodies — polygenic risk
10. Parkinson's disease — polygenic risk

Sensory aging

1. Cataracts — polygenic risk
2. Age-related macular degeneration — polygenic risk
3. Age-related hearing loss — polygenic risk

Bone aging and fractures

1. Bone mineral density — polygenic risk
2. Osteoporosis — polygenic risk
3. Fractures — polygenic risk
4. Hip fracture — polygenic risk

Reproductive and visible markers of aging

1. Skin aging — polygenic risk
2. Hair graying — polygenic risk

Individual genetic variants — type: functional variant

1. FOXO3 rs2802292 [longevity] — functional variant
2. CDKN2B-AS1 rs4977574 [cardiometabolic / aging] — functional variant
3. CHRNA5 D398N (rs16969968) [nicotine dependence] — functional variant
4. OBFC1/STN1 rs9420907 [telomere length] — functional variant
5. POLD3 rs11236203 [telomere length] — functional variant
6. RTEL1 rs755017 [telomere length] — functional variant
7. TERC-region rs10936599 [telomere length] — functional variant
8. KL-VS / KLOTHO F352V (rs9536314) [Klotho / longevity] — functional variant
9. CAT −262C>T (rs1001179) [catalase / oxidative stress] — functional variant
10. SOD2 Val16Ala (rs4880) [oxidative stress / aging] — functional variant
11. GPX1 P198L (rs1050450) — functional variant
12. GDF5 rs143384 [osteoarthritis / joints] — functional variant
13. SLC39A8 A391T (rs13107325) [manganese / frailty] — functional variant
14. TGFA rs958685 [joint / cleft] — functional variant
15. ARMS2 A69S (rs10490924) [macular degeneration] — functional variant
16. CFH Y402H (rs1061170) [macular degeneration] — functional variant
17. TERT rs2736100 [telomere / cancer] — functional variant
18. C3 R102G (rs2230199) [macular degeneration] — functional variant

Composite scores — type: composite score

Summary scores calculated from the indicators of this direction. They are provided in the Report in addition and are not included in the number of indicators stated above.

1. Lifespan, healthspan & integrated aging (combined profile) — composite score
2. Frailty, mobility & physical resilience (combined profile) — composite score
3. Brain & cognitive aging (combined risk) — composite score

5. PANELS (COMPLETE SERVICES)

5.1. A Panel is a comprehensive Service that combines a DNA kit, laboratory analysis and the interpretation of several Tests in a single order at a reduced price. Each Panel includes a DNA kit and laboratory analysis.

5.2. Prisma

The "Prisma" Service is one Test of the Customer's choice out of the 26 Apixmed Prism directions. The number of indicators depends on the direction selected and ranges from 22 to 71 indicators (see clauses 4.2-4.27).

The composition includes:

1. DNA kit (saliva collection + laboratory analysis + delivery)
2. One Test of the Customer's choice
3. Genetic report in PDF format
4. Raw genetic data file

5.3. Wellness Panel

A comprehensive panel for assessing health, lifestyle and prevention — a universal starter set. It covers 5 Tests with a total of 220 unique indicators: 161 complex indicators and 59 individual genetic variants. The directions of the panel do not overlap — each indicator is included in it once.

The composition includes:

1. DNA kit (saliva collection + laboratory analysis + delivery)
2. "Vitamins and Micronutrients" Test — 58 indicators
3. "Glucose and Metabolic Syndrome" Test — 51 indicators
4. "Cardiovascular Health" Test — 46 indicators
5. "Mental Health and Personality" Test — 39 indicators
6. "Sleep and Circadian Rhythms" Test — 26 indicators
7. Genetic report in PDF format
8. Raw genetic data file

5.4. Ultima Panel

The full panel includes all directions of the Apixmed Prism programme. The panel covers 25 directions: the "Women's Health" and "Men's Health" directions are provided separately, and only one of the two is relevant for each Customer. The total scope is more than 1,000 indicators, including more than 720 complex indicators and more than 270 individual genetic variants.

The composition includes:

1. DNA kit (saliva collection + laboratory analysis + delivery)
2. "Vitamins and Micronutrients" Test — 58 indicators
3. "Amino Acids" Test — 43 indicators
4. "Blood Biomarkers" Test — 52 indicators
5. "Lipids, Cholesterol and Fatty Acids" Test — 50 indicators
6. "Cardiovascular Health" Test — 46 indicators
7. "Glucose and Metabolic Syndrome" Test — 51 indicators
8. "Liver, Gallbladder and Pancreas" Test — 38 indicators
9. "Digestive System Health and Microbiome" Test — 26 indicators
10. "Kidneys and Urinary Tract" Test — 29 indicators
11. "Thyroid, Adrenal and Parathyroid" Test — 39 indicators
12. "Reproductive, Growth and Metabolic Hormones" Test — 30 indicators
13. "Women's Health" Test — 71 indicators
14. "Men's Health" Test — 34 indicators
15. "Cancer Risks" Test — 55 indicators
16. "Allergies and Intolerances" Test — 28 indicators
17. "Immunity, Infections and Autoimmune Conditions" Test — 57 indicators
18. "Respiratory System Health" Test — 22 indicators
19. "Mental Health and Personality" Test — 39 indicators
20. "Sleep and Circadian Rhythms" Test — 26 indicators
21. "Addictions and Behavior" Test — 33 indicators
22. "Eye and Ear Health" Test — 42 indicators
23. "Dental and Oral Health" Test — 35 indicators
24. "Skin, Hair and Appearance" Test — 51 indicators
25. "Musculoskeletal System, Injury and Recovery" Test — 37 indicators
26. "Athletic Potential and Physical Performance" Test — 25 indicators
27. "Longevity and Biological Aging" Test — 53 indicators
28. Special sections of the Report (included automatically in the Ultima Panel)
29. Genetic report in PDF format
30. Raw genetic data file
31. One online consultation with a geneticist regarding the results of the Report

6. WARNINGS

6.1. The results of all Services are for informational purposes only and reflect genetic predispositions, not the presence of a disease. They are not a medical diagnosis, do not replace a doctor's consultation, and cannot be a basis for self-medication.

6.2. The Contractor does not guarantee the detection of all possible genetic variants — the scope of the analysis is limited by the current state of science, the genotyping technology applied and the capabilities of wellness interpretation.

6.3. Complex indicators describe a relative shift in predisposition compared with a reference population and are not a measurement of the indicator.

6.4. Individual genetic variants, including variants of genes associated with hereditary cancer syndromes, are determined by genotyping at predefined positions and are of a screening nature. Such a result is not a diagnosis and cannot be a basis for medical decisions: for clinical use it requires independent confirmation by a validated diagnostic method in an accredited clinical laboratory and a consultation with a medical geneticist. The absence of a detected variant does not exclude the presence of other variants in the same gene, since the analysis covers only selected positions and not the full sequence of the gene.