Blood biomarkers

Why doesn't standard blood biochemistry always explain what's happening with metabolism?

A biochemical blood test records the current values — glucose, cholesterol, hormone levels — at the time of collection. But behind these numbers lies a more complex system: how sensitive cells are to insulin, how lipid metabolism is regulated, how intensely the body responds to inflammatory signals. Each of these processes is influenced by hereditary characteristics — and they remain stable regardless of what the analysis shows today.

For example, two men with the same total cholesterol level may have fundamentally different cardiovascular risk if one of them has a genetically reduced ability to synthesize apolipoprotein A1, which transports “good” cholesterol. 

Another example is the leptin receptor: genetic variants can affect how effectively the brain receives the satiety signal, and this is not reflected in any standard analysis. 

This genetic blood test assesses inherited metabolic profile features — 23 parameters covering glucose and lipid metabolism, markers of systemic inflammation, and hormonal regulation as part of a single metabolic system. These data are stable throughout life and complement the results of biochemical analyses.

What indicators does the test evaluate?

Blood and hemoglobin

Hemoglobin level , transport iron and methylmalonic acid are three indicators that together provide a genetic context for assessing oxygen transport and cellular energy metabolism. Methylmalonic acid is a marker of functional vitamin B12 availability: its level can increase even when serum B12 is formally normal. Hereditary features associated with the efficiency of iron absorption and functional B12 status are determined. 

Metabolism and weight

This is the largest block of the package — 8 indicators covering key links in carbohydrate metabolism and body weight regulation.

• Fasting glucose and insulin sensitivity — this genetic insulin resistance test identifies predisposition before it becomes clinically apparent.

• Metabolic syndrome and type 2 diabetes — hereditary risk factors associated with disorders of carbohydrate and lipid metabolism are analyzed.

• Obesity, BMI and leptin receptor - genetic features of appetite regulation, satiety signals and the tendency to accumulate adipose tissue are assessed.

• Hyperlipidemia — hereditary factors that affect blood lipid levels are identified.

Cholesterol and inflammatory markers

Five indicators reflecting lipid profile genetics and inflammatory risk.

• Total cholesterol and HDL cholesterol — as part of this genetic cholesterol test, hereditary features of lipid metabolism and the ratio of fractions are analyzed.

• Apolipoprotein A1 is a key protein in reverse cholesterol transport. Genetic variants affect the body's ability to remove excess cholesterol from blood vessel walls.

• Homocysteine — elevated levels are associated with the risk of vascular disorders. Genetic variants are associated with a tendency to accumulate it regardless of diet.

• C-reactive protein (CRP) is one of the key systemic inflammation markers. Hereditary features of the intensity of the inflammatory response are determined.

Hormonal regulation

Seven indicators — cortisol, adrenaline, serotonin, oxytocin, somatotropin, thyroid hormones and genetic predisposition to hypothyroidism. In the context of metabolic profile, these hormones are considered as regulators of metabolic processes: cortisol and adrenaline affect glucose levels and lipid metabolism; cortisol is also linked to weight regulation; serotonin and oxytocin — on eating behavior and stress response, thyroid hormones — on basal metabolism and energy balance. Hereditary features of synthesis, transport and receptor sensitivity of each of the indicators are determined.

Who is this test relevant to?

• For people who are overweight or who notice that changes in diet and regimen give unpredictable results - to assess genetic features of weight regulation, appetite, and carbohydrate metabolism.

• For those with a family history of cardiovascular disease, type 2 diabetes, or lipid disorders, a genetic profile provides context for a preventive approach with your doctor.

• People with chronic fatigue, unstable energy levels, or impaired concentration — to assess hereditary characteristics related to hormonal regulation and cellular energy metabolism.

• For those who regularly undergo biochemical blood tests: a genetic blood test provides the individual context behind your indicators

The results of this DNA biomarkers test are not a diagnosis and do not replace a doctor's consultation. The Apixmed Prism report builds a personalized metabolic profile based on your DNA — data that complements biochemical tests and helps make decisions about nutrition, lifestyle and prevention together with your doctor.